Reaction mechanism, free energy profiles and structural changes along the reaction path of catalysis in the wild type and two active site mutants of medium chain acyl-CoA dehydrogenase.

被引：0

作者：

Bhattacharyay, S ^{[1
]}

Stankovich, MT ^{[1
]}

Gao, J ^{[1
]}

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 228卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

203-COMP

引用

页码：U531 / U531

页数：1

共 8 条

[1] Solvent isotope effects in reactions of human medium-chain acyl-CoA dehydrogenase active site mutants
Gradinaru, Robert
Schowen, Richard
Ghisla, Sandro
BIOCHEMISTRY, 2007, 46 (09) : 2497 - 2509
[2] Free energy surface, reaction paths, and kinetic isotope effect of short-chain Acyl-CoA dehydrogenase
Poulsen, TD
Garcia-Viloca, M
Gao, JL
Truhlar, DG
JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (35): : 9567 - 9578
[3] CHARACTERIZATION OF WILD-TYPE AND AN ACTIVE-SITE MUTANT OF HUMAN MEDIUM CHAIN ACYL-COA DEHYDROGENASE AFTER EXPRESSION IN ESCHERICHIA-COLI
BROSS, P
ENGST, S
STRAUSS, AW
KELLY, DP
RASCHED, I
GHISLA, S
JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (13) : 7116 - 7119
[4] EXPRESSION AND CHARACTERIZATION OF WILD-TYPE AND AN ACTIVE-SITE MUTANT OF HUMAN LONG-CHAIN ACYL-COA DEHYDROGENASE IN ESCHERICHIA-COLI
DONG, Y
KRAENTLE, FG
KIM, JJ
GHISLA, S
RASCHED, I
STRAUSS, AW
FASEB JOURNAL, 1993, 7 (03): : A169 - A169
[5] CHARACTERIZATION OF WILD-TYPE AND AN ACTIVE-SITE MUTANT IN ESCHERICHIA-COLI OF SHORT-CHAIN ACYL-COA DEHYDROGENASE FROM MEGASPHAERA-ELSDENII
BECKER, DF
FUCHS, JA
BANFIELD, DK
FUNK, WD
MACGILLIVRAY, RTA
STANKOVICH, MT
BIOCHEMISTRY, 1993, 32 (40) : 10736 - 10742
[6] MICROSCOPIC PATHWAY FOR THE MEDIUM-CHAIN FATTY ACYL COA DEHYDROGENASE CATALYZED OXIDATIVE HALF-REACTION - CHANGES IN THE ELECTRONIC-STRUCTURES OF FLAVIN AND COA DERIVATIVES DURING CATALYSIS
JOHNSON, JK
KUMAR, NR
SRIVASTAVA, DK
BIOCHEMISTRY, 1993, 32 (43) : 11575 - 11585
[7] MOLECULAR-BASIS OF THE MEDIUM-CHAIN FATTY ACYL-COA DEHYDROGENASE-CATALYZED OXIDASE REACTION - PH-DEPENDENT DISTRIBUTION OF INTERMEDIARY ENZYME SPECIES DURING CATALYSIS
JOHNSON, JK
KUMAR, NR
SRIVASTAVA, DK
BIOCHEMISTRY, 1994, 33 (15) : 4738 - 4744
[8] Thermodynamics of ligand binding and catalysis in human liver medium-chain acyl-CoA dehydrogenase:: Comparative studies involving normal and 3′-dephosphorylated C8-CoAs and wild-type and Asn191→Ala(N191A) mutant enzymes
Peterson, KL
Peterson, KM
Srivastava, DK
BIOCHEMISTRY, 1998, 37 (36) : 12659 - 12671

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