Analogues of hexitol nucleic acids: Structure function relationship of a new steric blocking agent

被引：0

作者：

Van Aerschot, A ^{[1
]}

Maurinsh, Y ^{[1
]}

Allart, B ^{[1
]}

Boudou, V ^{[1
]}

Herdewijn, P ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

CHEMISTRY OF NUCLEIC ACID COMPONENTS | 1999年 / 2卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Different base and sugar modifications have been evaluated to increase the base-pairing potential of hexitol nucleic acids. Introduction of 5-methyl groups for pyrimidines, substitution of 2,6-diaminopurine for adenine as well as introduction of a supplementary hydroxyl moiety; at 3'-down-position all proved advantagous. Removal of the ring oxygen resulting in cyclohexyl nucleic acid analogues still allowed base-pairing with a natural complement.

引用

页码：100 / 104

页数：5

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