Impact of Variations in Test Method Parameters on In Vitro Activity of Surotomycin against Clostridium difficile and Surotomycin Quality Control Limits for Broth Microdilution and Agar Dilution Susceptibility Testing

被引：0
|
作者：
Traczewski, Maria M. [1 ]
Deane, Jennifer [2 ,4 ]
Sahm, Daniel [2 ,5 ]
Brown, Steven D. [1 ]
Chesnel, Laurent [3 ]
机构：
[1] Inst Clin Microbiol, Wilsonville, OR USA
[2] Eurofins Medinet, Chantilly, VA USA
[3] Merck & Co Inc, Kenilworth, NJ USA
[4] ATCC, Manassas, VA USA
[5] Int Hlth Management Associates Inc, Schaumburg, IL USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2016年 / 54卷 / 03期
关键词：
UNITED-STATES; INFECTION; METRONIDAZOLE; VANCOMYCIN; CB-183,315; EPIDEMIOLOGY; LIPOPEPTIDE; MORTALITY; INCREASE;
D O I：
10.1128/JCM.02881-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Test parameter variations were evaluated for their effects on surotomycin MICs. Calcium concentration was the only variable that influenced MICs; therefore, 50 mu g/ml (standard for lipopeptide testing) is recommended. Quality control ranges for Clostridium difficile (0.12 to 1 mu g/ml) and Eggerthella lenta (broth, 1 to 4 mu g/ml; agar, 1 to 8 mu g/ml) were approved by the Clinical and Laboratory Standards Institute based on these data.
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收藏
页码：749 / 753
页数：5
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