Leucine zipper as a fine tuner for the DNA binding; Revisited with molecular dynamics simulation of the Fos-Jun bZIP complex

被引：0
|
作者：
Choi, YH
Yang, CH
Kim, HW
Jung, S
机构：
[1] Konkuk Univ, Dept Microbial Engn, Kwangjin Ku, Seoul 143701, South Korea
[2] Seoul Natl Univ, Dept Chem, Seoul 151742, South Korea
[3] Yonsei Univ, Wonju Coll Med, Dept Biochem, Wonju 220701, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 1999年 / 20卷 / 11期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Leucine zipper dynamically tunes the degree of bifurcation of the DNA binding segments in the basic region of the Foe-Jun bZIP complex. Molecular dynamics simulation indicated that site-specific mutagenesis of conserved leucine residues inside the leucine zipper domain caused the change of dynamic behavior of the basic region, and efficient DNA binding occurs only within a certain range of distance between the two DNA binding segments in the basic region. Distribution of alpha-helices in the hinge region is also suggested to influence the bifurcation of the DNA binding segments.
引用
收藏
页码：1319 / 1322
页数：4
相关论文
共 13 条
12