Synthesis of highly potent HIV protease inhibitors with activity against protease resistant virus.

被引：0
|
作者：
Lu, ZJ
Raghavan, S
Charest, M
Stahlhut, MW
Rutkowski, CA
Himmelberger, AL
Olsen, DB
Schleif, WA
Carella, A
Gabryelski, L
Jin, LX
Lin, JH
Tata, JA
机构：
[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA
[2] Merck Res Labs, Dept Antiviral Res, Rahway, NJ 07065 USA
[3] Merck Res Labs, Dept Drug Metab, Rahway, NJ 07065 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 224卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
025-MEDI
引用
收藏
页码：U9 / U9
页数：1
相关论文
共 50 条
  • [1] Design and synthesis of highly potent HIV protease inhibitors with activity against protease resistant virus.
    Lu, ZJ
    Raghavan, S
    Bohn, J
    Charest, M
    Stahlhut, MW
    Rutkowski, CA
    Himmelberger, AL
    Olsen, DB
    Schleif, WA
    Carella, A
    Gabryelski, L
    Jin, LX
    Lin, JH
    Tata, JR
    Chapman, K
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U41 - U41
  • [2] Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus
    Lu, ZJ
    Raghavan, S
    Bohn, J
    Charest, M
    Stahlhut, MW
    Rutkowski, CA
    Simcoe, AL
    Olsen, DB
    Schleif, WA
    Carella, A
    Gabryelski, L
    Jin, LX
    Lin, JH
    Emini, E
    Chapman, K
    Tata, JR
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (10) : 1821 - 1824
  • [3] Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus
    Lu, ZJ
    Bohn, J
    Rano, T
    Rutkowski, CA
    Simcoe, AL
    Olsen, DB
    Schleif, WA
    Carella, A
    Gabryelski, L
    Jin, LX
    Lin, JH
    Emini, E
    Chapman, K
    Tata, JR
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (23) : 5311 - 5314
  • [4] Highly potent HIV protease inhibitors with broad activity against MDR strains
    Gulnik, SV
    Afonina, E
    Yu, B
    Eissenstat, M
    Guerassina, T
    Silva, AM
    Erickson, JW
    ANTIVIRAL THERAPY, 2004, 9 (04) : U29 - U29
  • [5] Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus
    Raghavan, Subharekha
    Lu, Zhijian
    Beeson, Teresa
    Chapman, Kevin T.
    Schleif, William A.
    Olsen, David B.
    Stahlhut, Mark
    Rutkowski, Carrie A.
    Gabryelski, Lori
    Emini, Emilio
    Tata, James R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (19) : 5432 - 5436
  • [6] Second generation HIV protease inhibitors against resistant virus
    Lu, Zhijian
    EXPERT OPINION ON DRUG DISCOVERY, 2008, 3 (07) : 775 - 786
  • [7] Synthesis and activity of HIV protease inhibitors
    Garrouste, P
    Pawlowski, M
    Tonnaire, T
    Sicsic, S
    Dumy, P
    de Rosny, E
    Reboud-Ravaux, M
    Fulcrand, P
    Martinez, J
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (06) : 423 - 436
  • [8] Design and synthesis of bicyclic piperazine sulfonamides leading to highly potent HIV protease inhibitors
    Bungard, Christopher
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [9] Oximinoarylsulfonamides as potent HIV protease inhibitors
    Yeung, CM
    Klein, LL
    Flentge, CA
    Randolph, JT
    Zhao, C
    Sun, MH
    Dekhtyar, T
    Stoll, VS
    Kempf, DJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (09) : 2275 - 2278
  • [10] Metallacarboranes as specific and potent inhibitors of HIV protease and its resistant mutants
    Pokorná, J.
    Cígler, P.
    Kozísek, M.
    Rezácová, P.
    Brynda, J.
    Plesek, J.
    Gruner, B.
    Sedlácek, J.
    Bodem, J.
    Kraeusslich, H-G
    Král, V.
    Konvalinka, J.
    ANTIVIRAL THERAPY, 2006, 11 (05) : S29 - S29
12345