New horizons in adjuvants for vaccine development

被引：498
|
作者：
Reed, Steven G. [1 ]
Bertholet, Sylvie [1 ]
Coler, Rhea N. [1 ]
Friede, Martin [2 ]
机构：
[1] Infect Dis Res Inst, Seattle, WA 98104 USA
[2] WHO, CH-1211 Geneva 27, Switzerland
来源：
TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 01期
关键词：
HEPATITIS-B-VACCINE; INFLUENZA VACCINE; IMMUNE-RESPONSES; ALUMINUM-HYDROXIDE; MALARIA VACCINE; CROSS-PRESENTATION; DENDRITIC CELLS; T-CELLS; IMMUNOGENICITY; RECOMBINANT;
D O I：
10.1016/j.it.2008.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Over the last decade, there has been a flurry of research on adjuvants for vaccines, and several novel adjuvants are now in licensed products or in late stage clinical development. The success of adjuvants in enhancing the immune response to recombinant antigens has led many researchers to re-focus their vaccine development programs. Successful vaccine development requires knowing which adjuvants to use and knowing how to formulate adjuvants and antigens to achieve stable, safe and immunogenic vaccines. For the majority of vaccine researchers this information is not readily available, nor is access to well-characterized adjuvants. In this review, we outline the current state of adjuvant research and development and how formulation parameters can influence the effectiveness of adjuvants.
引用
收藏
页码：23 / 32
页数：10
相关论文
共 50 条
  • [1] New horizons in adjuvants for vaccine development
    Reed, Steven G.
    Tomai, Mark
    Gale, Michael J., Jr.
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2020, 65 : 97 - 101
  • [2] Prospects for the development of new vaccine adjuvants
    Cox, J
    Coulter, A
    [J]. BIODRUGS, 1999, 12 (06) : 439 - 453
  • [3] Prospects for the Development of New Vaccine Adjuvants
    John C Cox
    Alan Coulter
    [J]. BioDrugs, 1999, 12 : 439 - 453
  • [4] Adjuvants in tuberculosis vaccine development
    Moreno-Mendieta, Silvia A.
    Rocha-Zavaleta, Leticia
    Rodriguez-Sanoja, Romina
    [J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2010, 58 (01): : 75 - 84
  • [5] Development of thermostable vaccine adjuvants
    Qi, Yizhi
    Fox, Christopher B.
    [J]. EXPERT REVIEW OF VACCINES, 2021, 20 (05) : 497 - 517
  • [6] Adjuvants and malaria vaccine development
    Xiao, LH
    Rafi-Janajreh, A
    Patterson, P
    Zhou, ZY
    Lal, AA
    [J]. MALARIA IMMUNOLOGY, 2ND EDITION, 2002, 80 : 343 - 365
  • [7] The development and use of vaccine Adjuvants
    Edelman, R
    [J]. MOLECULAR BIOTECHNOLOGY, 2002, 21 (02) : 129 - 148
  • [8] Novel adjuvants in vaccine development
    Kaufmann A.M.
    Schmidt-Ott R.
    Prechtl A.
    [J]. MMW - Fortschritte der Medizin, 2010, 152 (Suppl 4) : 115 - 118
  • [9] The development and use of vaccine adjuvants
    Robert Edelman
    [J]. Molecular Biotechnology, 2002, 21 : 129 - 148
  • [10] New-age vaccine adjuvants, their development, and future perspective
    Verma, Shailendra Kumar
    Mahajan, Pooja
    Singh, Nikhlesh K.
    Gupta, Ankit
    Aggarwal, Rupesh
    Rappuoli, Rino
    Johri, Atul Kumar
    [J]. FRONTIERS IN IMMUNOLOGY, 2023, 14
12345