Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus

被引:144
|
作者
Aida, Yoko [1 ]
Murakami, Hironobu [1 ,2 ]
Takahashi, Masahiko [3 ]
Takeshima, Shin-Nosuke [1 ]
机构
[1] RIKEN, Viral Infect Dis Unit, Wako, Saitama 3510198, Japan
[2] Azabu Univ, Lab Anim Hlth 2, Sagamihara, Kanagawa, Japan
[3] Niigata Univ, Grad Sch Med & Dent Sci, Div Virol, Niigata, Japan
来源
基金
日本学术振兴会;
关键词
BLV; HTLV-1; EBL; B-cell lymphoma; Tax; leukemogensis; transactivation; apoptosis; BLOOD MONONUCLEAR-CELLS; LONG TERMINAL REPEAT; OPEN READING FRAMES; CLASS-II HAPLOTYPES; EXPRESSION IN-VIVO; NF-KAPPA-B; HTLV-I; TAX PROTEIN; PERSISTENT LYMPHOCYTOSIS; TRANSACTIVATOR PROTEIN;
D O I
10.3389/fmicb.2013.00328
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bovine leukemia virus (BLV) and human T-cell leukemia virus type 1 (HTLV-1) make up a unique retrovirus family. Both viruses induce chronic lymphoproliferative diseases with BLV affecting the B-cell lineage and HTLV-1 affecting the T-cell lineage. The pathologies of BLV- and HTLV-induced infections are notably similar, with an absence of chronic viraemia and a long latency period. These viruses encode at least two regulatory proteins, namely, Tax and Rex, in the pX region located between the env gene and the 3' long terminal repeat. The Tax protein is a key contributor to the oncogenic potential of the virus, and is also the key protein involved in viral replication. However, BLV infection is not sufficient for leukemogenesis, and additional events such as gene mutations must take place. In this review, we first summarize the similarities between the two viruses in terms of genomic organization, virology, and pathology. We then describe the current knowledge of the BLV model, which may also be relevant for the understanding of leukemogenesis caused by HTLV-1. In addition, we address our improved understanding of Tax functions through the newly identified BLVTax mutants, which have a substitution between amino acids 240 and 265.
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页数:11
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