Pediatric Human Immunodeficiency Virus infection and cancer in the Highly Active Antiretroviral Treatment (HAART) era

被引：26
|
作者：
Chiappini, Elena [1 ]
Berti, Elettra [1 ]
Gianesin, Ketty [2 ]
Petrara, Maria Raffaella [2 ]
Galli, Luisa [1 ]
Giaquinto, Carlo [3 ]
de Martino, Maurizio [1 ]
De Rossi, Anita [2 ,4 ]
机构：
[1] Anna Meyer Childrens Univ Hosp, Dept Hlth Sci, Florence, Italy
[2] Univ Padua, Dept Surg Oncol & Gastroenterol DiSCOC, Sect Oncol & Immunol, Padua, Italy
[3] Univ Padua, Dept Pediat, Padua, Italy
[4] IRCCS, IOV, I-35128 Padua, Italy
来源：
CANCER LETTERS | 2014年 / 347卷 / 01期
关键词：
HIV-related cancer; Children; HAART; Immune activation; Aging; TO-CHILD TRANSMISSION; EPSTEIN-BARR-VIRUS; PERINATALLY HIV-1-INFECTED CHILDREN; REVERSE-TRANSCRIPTASE INHIBITORS; EXPOSED IN-UTERO; HIV-INFECTION; 1-INFECTED CHILDREN; PROTEASE INHIBITORS; IMMUNE ACTIVATION; THYMIC OUTPUT;
D O I：
10.1016/j.canlet.2014.02.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is increasing. HIV-associated immune activation and inflammation, promoting tumorigenesis, can only partially be reduced by HAART. In addition, HIV-infected children may undergo accelerated immune senescence that favors cancer development. How HAART affects this condition is an open question. Lastly, there is no evidence that prenatal exposure to HAART increases the risk of cancer in childhood, but long-term studies are needed. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.
引用
收藏
页码：38 / 45
页数：8
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