Inhibition of dopamine transport and binding of [3H] spiperone to dopamine D2 receptor by acute Pb -: Toxicity in vivo

被引：0
|
作者：
Sulkowski, G [1 ]
Dabrowska-Bouta, B [1 ]
Waskiewicz, J [1 ]
Rafalowska, U [1 ]
机构：
[1] Polish Acad Sci, Med Res Ctr, Dept Neurochem, Lab Pathobiochem Cent Nervous Syst, PL-02106 Warsaw, Poland
来源：
FOLIA NEUROPATHOLOGICA | 1999年 / 37卷 / 04期
关键词：
acute lead toxicity; dopamine transport; receptor;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alterations of dopamine transport and binding of [H-3] spiperone to dopamine D-2 receptor following acute lead intoxication in an in vivo experimental model in adult rats imitate the acute action of Pb2+ in occupationally exposed workers or in occasional incidents of poisoning. The results show that lead-intoxication causes an increased Pb level in blood, a decrease in dopamine uptake and release in synaptosomes and affects the dopamine D-2 receptor. These data show that Ph-intoxication may cause severe disturbances in the transport and receptor binding of dopamine, which is involed in the regulation of a variety of functions including locomotor activity, emotion and neuroendocrine secretion.
引用
收藏
页码：205 / 209
页数：5
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