Animal Models for Tuberculosis in Translational and Precision Medicine

被引：37
|
作者：
Zhan, Lingjun [1 ,2 ,3 ,4 ,5 ,6 ]
Tang, Jun [1 ,2 ,3 ,4 ,5 ,6 ]
Sun, Mengmeng [1 ,2 ,3 ,4 ,5 ,6 ]
Qin, Chuan [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Minist Hlth, Key Lab Human Dis Comparat Med, Beijing, Peoples R China
[2] Chinese Acad Med Sci, Inst Lab Anim Sci Ctr TB, Beijing, Peoples R China
[3] Peking Union Med Coll, Beijing, Peoples R China
[4] Beijing Key Lab Anim Models Emerging & Reemerging, Beijing, Peoples R China
[5] Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China
[6] State Adm Tradit Chinese Med, Key Lab Human Dis Anim Model, Beijing, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2017年 / 8卷
关键词：
tuberculosis; animal models; comparative medicine; translational medicine; precision medicine; REPORTER ENZYME FLUORESCENCE; C3HEB/FEJ MOUSE MODEL; NITRIC-OXIDE SYNTHASE; MYCOBACTERIUM-TUBERCULOSIS; LATENT TUBERCULOSIS; PROGNOSTIC-FACTORS; PULMONARY TUBERCULOSIS; RESISTANT TUBERCULOSIS; UTERINE SARCOMA; TREATMENT RESPONSE;
D O I：
10.3389/fmicb.2017.00717
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for identification of targets; thus, they serve as the cornerstone of comparative medicine, translational medicine, and precision medicine. In this review, we discuss the current use of TB animal models and their problems, as well as offering perspectives on the future of these models.
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页数：12
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