Approaches to identify and characterize microProteins and their potential uses in biotechnology

被引：24

作者：

Bhati, Kaushal Kumar ^{[1
,2
]}

Blaakmeer, Anko ^{[1
,2
]}

Paredes, Esther Botterweg ^{[1
,2
]}

Dolde, Ulla ^{[1
,2
]}

Eguen, Tenai ^{[1
,2
]}

Hong, Shin-Young ^{[1
,2
]}

Rodrigues, Vandasue ^{[1
,2
]}

Straub, Daniel ^{[1
,2
]}

Sun, Bin ^{[1
,2
]}

Wenkel, Stephan ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark

[2] Univ Copenhagen, Copenhagen Plant Sci Ctr, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2018年 / 75卷 / 14期

基金：

欧洲研究理事会;

关键词：

MicroProtein; Small proteins; Targets; Complex; MiPFinder; Inhibition; Protein-protein interaction; GENOME-WIDE IDENTIFICATION; PROTEOLYTIC EVENTS; REGULATORY MODULE; ARABIDOPSIS; CLEAVAGE; INHIBITOR; LOOP;

D O I：

10.1007/s00018-018-2818-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroProteins are small proteins that contain a single protein domain and are related to larger, often multi-domain proteins. At the molecular level, microProteins act by interfering with the formation of higher order protein complexes. In the past years, several microProteins have been identified in plants and animals that strongly influence biological processes. Due to their ability to act as dominant regulators in a targeted manner, microProteins have a high potential for biotechnological use. In this review, we present different ways in which microProteins are generated and we elaborate on techniques used to identify and characterize them. Finally, we give an outlook on possible applications in biotechnology.

引用

页码：2529 / 2536

页数：8

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