Iron(II)-Catalyzed Asymmetric Epoxidation of Trisubstituted α,β-Unsaturated Esters

被引：17
|
作者：
Luo, Lan [1 ]
Yamamoto, Hisashi [1 ,2 ]
机构：
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
[2] Chubu Univ, Mol Catalyst Res Ctr, Kasugai, Aichi 4878501, Japan
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 35期
基金：
美国国家卫生研究院;
关键词：
Synthetic methods; Asymmetric synthesis; Epoxidation; Enantioselectivity; Iron; HIGHLY ENANTIOSELECTIVE EPOXIDATION; KETONES; OLEFINS;
D O I：
10.1002/ejoc.201403220
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric epoxidation of trisubstituted ,-unsaturated esters was developed. The oxidation utilizes a pseudo-C-2-symmetric iron(II) catalyst [Fe(L*)(2)(CH3CN)(OTf)](OTf) (Tf = trifluoromethylsulfonyl) and peracetic acid as oxidant and yields ,-epoxy esters with high enantiomeric purity (up to 99%ee).
引用
收藏
页码：7803 / 7805
页数：3
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