N-methyl-D-aspartate Receptor Antagonist Ketamine Impairs Action-monitoring Activity in the Prefrontal Cortex

被引:10
|
作者
Skoblenick, Kevin [1 ]
Everling, Stefan [1 ]
机构
[1] Univ Western Ontario, London, ON N6A 3K7, Canada
基金
加拿大健康研究院;
关键词
ANTERIOR CINGULATE CORTEX; ERROR-RELATED NEGATIVITY; SCHIZOPHRENIC-PATIENTS; VOLUNTARY CONTROL; ANTISACCADE TASK; EYE-MOVEMENTS; PERFORMANCE; SACCADES; MONKEY; ECCENTRICITY;
D O I
10.1162/jocn_a_00519
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Failures in monitoring of self-generated actions are thought to underlie the positive symptoms in schizophrenia. It has been hypothesized that these deficits may be caused by a dysfunction of N-methyl-D-aspartate receptors (NMDARs). Here we recorded the activity of prefrontal neurons in monkeys performing an antisaccade task, while we administered a sub-anesthetic dose of the noncompetitive NMDAR antagonist ketamine. Many neurons discriminated between correct anti-saccades and response errors in their postresponse activity. Ketamine increased the activity for the neurons' nonpreferred response, thereby decreasing the neurons' performance selectivity. Ketamine also affected the monkeys' behavior after an error, consistent with a deficit in error detection. The results show that NMDARs play an important role in action monitoring in primates. The decrease in performance selectivity of prefrontal neurons after ketamine can help to explain the deficits in action monitoring found in humans after ketamine administration and provides support for the hypothesis that an NMDAR dysfunction underlies self-monitoring deficits and psychotic symptoms in schizophrenia.
引用
收藏
页码:577 / 592
页数:16
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