Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis

被引:66
|
作者
Hillard, Cecilia J. [1 ,2 ]
Beatka, Margaret [1 ,2 ]
Sarvaideo, Jenna [2 ,3 ]
机构
[1] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Neurosci Res Ctr, Milwaukee, WI 53226 USA
[3] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA
关键词
ACID AMIDE HYDROLASE; GLUCOCORTICOID-RECEPTOR ACTIVATION; CB1 CANNABINOID RECEPTORS; ANTIDEPRESSANT-LIKE ACTIVITY; MEDIAL PREFRONTAL CORTEX; ENTERIC NERVOUS-SYSTEM; BASOLATERAL AMYGDALA; RESTRAINT STRESS; ENDOGENOUS CANNABINOIDS; MEMORY CONSOLIDATION;
D O I
10.1002/cphy.c160005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The elucidation of Delta(9)-tetrahydrocannabinol as the active principal of Cannabis sativa in 1963 initiated a fruitful half-century of scientific discovery, culminating in the identification of the endocannabinoid signaling system, a previously unknown neuromodulatory system. A primary function of the endocannabinoid signaling system is to maintain or recover homeostasis following psychological and physiological threats. We provide a brief introduction to the endocannabinoid signaling system and its role in synaptic plasticity. The majority of the article is devoted to a summary of current knowledge regarding the role of endocannabinoid signaling as both a regulator of endocrine responses to stress and as an effector of glucocorticoid and corticotrophin-releasing hormone signaling in the brain. We summarize data demonstrating that cannabinoid receptor 1 (CB1R) signaling can both inhibit and potentiate the activation of the hypothalamic-pituitary-adrenal axis by stress. We present a hypothesis that the inhibitory arm has high endocannabinoid tone and also serves to enhance recovery to baseline following stress, while the potentiating arm is not tonically active but can be activated by exogenous agonists. We discuss recent findings that corticotropin-releasing hormone in the amygdala enables hypothalamic-pituitary-adrenal axis activation via an increase in the catabolism of the endocannabinoid N-arachidonylethanolamine. We review data supporting the hypotheses that CB1R activation is required for many glucocorticoid effects, particularly feedback inhibition of hypothalamic-pituitary-adrenal axis activation, and that glucocorticoids mobilize the endocannabinoid 2-arachidonoylglycerol. These features of endocannabinoid signaling make it a tantalizing therapeutic target for treatment of stress-related disorders but to date, this promise is largely unrealized. (C) 2017 American Physiological Society.
引用
收藏
页码:1 / 15
页数:15
相关论文
共 50 条
  • [1] Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic-Pituitary-Adrenal Axis
    Hill, Matthew N.
    McLaughlin, Ryan J.
    Morrish, Anna C.
    Viau, Victor
    Floresco, Stan B.
    Hillard, Cecilia J.
    Gorzalka, Boris B.
    [J]. NEUROPSYCHOPHARMACOLOGY, 2009, 34 (13) : 2733 - 2745
  • [2] Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Patel, S
    Roelke, CT
    Rademacher, DJ
    Cullinan, WE
    Hillard, CJ
    [J]. ENDOCRINOLOGY, 2004, 145 (12) : 5431 - 5438
  • [3] ENDOCANNABINOID SIGNALING, GLUCOCORTICOID-MEDIATED NEGATIVE FEEDBACK, AND REGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    Hill, M. N.
    Tasker, J. G.
    [J]. NEUROSCIENCE, 2012, 204 : 5 - 16
  • [4] The role of the endocannabinoid system in the regulation of hypothalamic-pituitary-adrenal axis activity
    Cota, D.
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2008, 20 : 35 - 38
  • [5] HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    HONOUR, JW
    [J]. RESPIRATORY MEDICINE, 1994, 88 : 9 - 15
  • [6] THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    FEEK, CM
    MARANTE, DJ
    EDWARDS, CRW
    [J]. CLINICS IN ENDOCRINOLOGY AND METABOLISM, 1983, 12 (03): : 597 - 618
  • [7] Hypothalamic-pituitary-adrenal axis in schizophrenia
    Altamura, AC
    [J]. BIOLOGICAL PSYCHIATRY, 1996, 40 (06) : 560 - 561
  • [8] Medicines of the hypothalamic-pituitary-adrenal axis
    Reyt, Vincent
    Buxeraud, Jacques
    [J]. ACTUALITES PHARMACEUTIQUES, 2018, 57 (574): : 19 - 21
  • [9] TESTING HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    不详
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1970, 1 (5697): : 644 - +
  • [10] THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN DEPRESSION
    MELTZER, HY
    LOWY, MT
    KOENIG, JI
    [J]. ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY, 1987, 43 : 165 - 182