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YjhS (NanS) Is Required for Escherichia coli To Grow on 9-O-Acetylated N-Acetylneuraminic Acid
被引:38
|作者:
Steenbergen, Susan M.
[1
]
Jirik, Jamie L.
[1
]
Vimr, Eric R.
[1
]
机构:
[1] Univ Illinois, Lab Sialobiol, Dept Pathobiol, Urbana, IL 61802 USA
关键词:
O-ACETYL ESTERASE;
SIALIC-ACID;
CARBON NUTRITION;
INTESTINAL-TRACT;
MOUSE INTESTINE;
METABOLISM;
CATABOLISM;
K1;
GLYCOSULFATASE;
IDENTIFICATION;
D O I:
10.1128/JB.01000-09
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The nanATEK-yhcH, yjhATS, and yjhBC operons in Escherichia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid in nature. Here we show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to grow on this alternative sialic acid, which is commonly found in mammalian host mucosal sites.
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页码:7134 / 7139
页数:6
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