Cross-Talk between Hemidesmosomes and Focal Adhesions: A Primer for Wound Healing, Blistering Skin Disease, and Skin Aging

被引：10
|
作者：
Hatzfeld, Mechthild [1 ]
Magin, Thomas M. [2 ]
机构：
[1] Martin Luther Univ Halle Wittenberg, Inst Mol Med, Div Pathobiochem, Halle, Germany
[2] Univ Leipzig, Inst Biol, Div Cell & Dev Biol, Leipzig, Germany
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2019年 / 139卷 / 09期
关键词：
INTEGRIN; CONTACTS; MIGRATION;
D O I：
10.1016/j.jid.2019.04.010
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Hemidesmosomes and focal adhesions attach keratinocytes to the dermis and act as bidirectional signaling centers to control epidermal renewal. Pora and colleagues (Pora et al., 2019) demonstrate that in migrating primary human keratinocytes, hemidesmosomes cluster as ordered arrays consisting of multiple chevrons, flanked by actin-associated focal adhesions. These and related findings have implications for wound healing, cancer invasion, blistering skin diseases, and skin aging.
引用
收藏
页码：1854 / 1856
页数：3
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