A mild and highly efficient Friedlander synthesis of quinolines in the presence of heterogeneous solid acid nano-catalyst

A simple highly versatile and efficient synthesis of various poly-substituted quinolines in the Friedlander condensation of 2-aminoarylketones with carbonyl compounds and beta-keto esters using Montmorrilonite K-10, zeolite, nano-crystalline sulfated zirconia (SZ) as a catalyst in ethanol at moderate temperature. The advantages of methods are short reaction times and milder conditions, easy work-up and purification of products by non-chromatographic methods. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency. (C) 2011 Production and hosting by Elsevier B. V. on behalf of King Saud University.