Detection of gamma-hydroxybutyric acid in gamma-butyrolactone dependence. Body fluids versus hair analysis

被引：0
|
作者：
Port, A. [1 ]
Olszewski, H. [2 ]
Walther, U. [3 ]
Buettner, A. [1 ]
Rentsch, D. [1 ]
机构：
[1] Univ Med Rostock, Inst Rechtsmed, D-18055 Rostock, Germany
[2] Univ Med Rostock, Klin Psychiat & Psychotherapie, D-18055 Rostock, Germany
[3] Univ Med Rostock, Inst Toxikol & Pharmakol, D-18055 Rostock, Germany
来源：
RECHTSMEDIZIN | 2014年 / 24卷 / 05期
关键词：
Liquid ecstasy; Gas chromatography-mass spectrometry; Substance withdrawal syndrome; Substance abuse detection; Forensic toxicology; LIQUID ECSTASY; DRUG; GHB; IDENTIFICATION; ABUSE;
D O I：
10.1007/s00194-014-0966-1
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Gamma-butyrolactone (GBL) is a potent solvent which is indispensable for industrial cleaning purposes. Unlike the metabolite gamma-hydroxybutyric acid (GHB) it is not subject to restrictions under the German Narcotics Act (BtMG) and therefore easily available in internet retailing. Studies proved a physical and mental dependence potential and complex, sometimes fatal developments in the treatment of GBL/GHB withdrawal syndromes. Because of the short half-life period it is often not possible to detect ingested GBL/GHB in blood and urine samples. In the present case interdisciplinary collaboration of psychiatry, toxicology and forensic medicine revealed a detailed consumption profile which could be verified by hair analysis. The application of hair analysis in GBL/GHB-associated cases offers information and starting points in routine forensic medicine work.
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页码：412 / 417
页数：6
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