In situ hybridization and immunogold localization of vascular endothelial growth factor receptor-2 on the pericytes of the chick chorioallantoic membrane

被引：12
|
作者：
Ribatti, D
Cruz, A
Nico, B
Favier, J
Vacca, A
Corsi, P
Roncali, L
Dammacco, F
机构：
[1] Univ Bari, Dept Human Anat & Histol, Sch Med, Policlin, I-70124 Bari, Italy
[2] Univ Bari, Dept Biomed Sci & Human Oncol, Sch Med, I-70124 Bari, Italy
[3] Univ Bari, Dept Physiol & Pharmacol, Sch Med, I-70124 Bari, Italy
[4] Coll France, F-75231 Paris, France
[5] INSERM, U36, Paris, France
来源：
CYTOKINE | 2002年 / 17卷 / 05期
关键词：
angiogenesis; chorioullantoic membrane; pericyte; VEGF; VEGFR-2;
D O I：
10.1006/cyto.2002.1002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper describes the expression of VEGF and of VEGFR-2 in the vasculature of the chorioallantoic membrane (CAM) as revealed by in situ hybridization and immunoelectron microscopy. Results showed that VEGFR-2 is expressed in both the endothelial cells and the pericytes, while VEGF in the chorionic epithelial cells. VEGF may therefore be released to promote both angiogenesis, by initiating an angiogenic response by endothelial cells expressing VEGFR-2, and the recruitment of pericytes along the capillary wall, playing also a crucial role in maturation and stabilization of the CAM blood vessels. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：262 / 265
页数：4
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