Solution-phase parallel synthesis of a pyridinium pyrazol-3-olate inner salt library using a three-component reaction

被引：4

作者：

Varga, L ^{[1
]}

Nagy, T ^{[1
]}

Dormán, G ^{[1
]}

Kálmán, F ^{[1
]}

Ürge, L ^{[1
]}

Darvas, F ^{[1
]}

机构：

[1] ComGenex Inc, H-1031 Budapest, Hungary

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2006年 / 8卷 / 03期

关键词：

D O I：

10.1021/cc0501514

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We present here the discovery of a novel, versatile, multicomponent reaction leading to various 4-[4-(pyridinium-1-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-pyrazol-3-olate inner salts. The structure of the unusual zwitterionic inner salts was elucidated, and the scope of the novel reaction was investigated. After rapid optimization, the reaction was adapted to parallel synthesis, and an 800-membered compound library was produced.

引用

页码：338 / 343

页数：6

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