Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes

Platinum (IV) complexes [Pt(L)(2)Cl-2] [where, L = benzyl-N-thiohydrazide (L-1), (benzyl-N-thio)-1,3-propanediamine (L-2), benzaldehyde-benzyl-N-thiohydrazone (L-3) and salicylaldehyde-benzyl-N-thiohydrazone (L-4)] have been synthesized. The thiohydrazide, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands were found to act in monobasic bidentate fashion. Analytical data reveal that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and H-1 NMR spectroscopic studies. In vitro antibacterial and cytotoxic studies have been carried out for some complexes. Various kinetic and thermodynamic parameters like order of reaction (n), activation energy (E-a), apparent activation entropy (S-#) and heat of reaction (Delta H) have also been carried out for some complexes. (c) 2006 Elsevier Ltd. All rights reserved.