Grand Research Challenges for Sustainable Industrial Biotechnology

被引：92
|
作者：
Straathof, Adrie J. J. [1 ]
Wahl, S. Aljoscha [1 ]
Benjamin, Kirsten R. [2 ]
Takors, Ralf [3 ]
Wierckx, Nick [4 ]
Noorman, Henk J. [1 ,5 ]
机构：
[1] Delft Univ Technol, Dept Biotechnol, Maasweg 9, NL-2629 HZ Delft, Netherlands
[2] Amyris, 5885 Hollis St,Suite 100, Emeryville, CA 94608 USA
[3] Univ Stuttgart, Inst Biochem Engn, Allmandring 31, D-70569 Stuttgart, Germany
[4] Forschungszentrum Julich, Inst Bio & Geosci IBG Biotechnol 1, D-52425 Julich, Germany
[5] DSM Biotechnol Ctr, POB 1, NL-2600 MA Delft, Netherlands
来源：
TRENDS IN BIOTECHNOLOGY | 2019年 / 37卷 / 10期
关键词：
LIFE-CYCLE ASSESSMENT; COMMODITY CHEMICALS; ESCHERICHIA-COLI; SCALE-DOWN; DESIGN; FERMENTATION; TECHNOLOGIES; FUTURE; YEAST; FACTORIES;
D O I：
10.1016/j.tibtech.2019.04.002
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.
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页码：1042 / 1050
页数：9
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