Toxoplasma gondii: Congenital transmission in a hamster model

被引：7
|
作者：
Freyre, A. [1 ]
Fialho, C. G. [3 ]
Bigatti, L. E. [3 ]
Araujo, F. A. P. [3 ]
Falcon, J. D. [1 ]
Mendez, J. [2 ]
Gonzalez, M. [2 ]
机构：
[1] Fac Vet, Dept Parasitol, Lab Toxoplasmosis, Montevideo 11600, Uruguay
[2] Fac Quim Montevideo, Parasitol Lab, Montevideo, Uruguay
[3] Univ Fed Rio Grande do Sul, Fac Vet, Lab Protozool, Porto Alegre, RS, Brazil
来源：
EXPERIMENTAL PARASITOLOGY | 2009年 / 122卷 / 02期
关键词：
Toxoplasma gondii; Congenital transmission; Hamster; VERTICAL DISEASE TRANSMISSION; BALB/C MICE; RAT MODEL; PROTECTIVE IMMUNITY; MURINE MODEL; ANIMAL-MODEL; MOUSE MODEL; INFECTION; CYSTS; RETINOCHOROIDITIS;
D O I：
10.1016/j.exppara.2009.02.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (n = 168). Of 32 females with a chronic toxoplasma infection, 3 transmitted Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis. (c) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：140 / 144
页数：5
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