Synthesis of densely functionalized α-methylene γ-butyrolactones via an organocatalytic one-pot allylic-alkylation-cyclization reaction

被引：10
|
作者：
Yan, Yong [1 ,2 ]
En, Da [1 ,2 ]
Zhuang, Zhe [1 ]
Guo, Yuan [2 ]
Liao, Wei-Wei [1 ]
机构：
[1] Jilin Univ, Coll Chem, Dept Organ Chem, Changchun 130012, Peoples R China
[2] NW Univ Xian, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Peoples R China
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 02期
关键词：
Organocatalysis; One-pot synthesis; Allylic alkylation; Cyclization; STEREOSELECTIVE-SYNTHESIS; CONSTRUCTION; HYDROGENATION; CYANOHYDRINS; DERIVATIVES;
D O I：
10.1016/j.tetlet.2013.11.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The tertiary amine-catalyzed one-pot allylic-alkylation-cyclization (AAC) reaction has been developed, which provided an efficient synthetic route for the preparation of densely functionalized alpha-methylene-gamma-cyano-gamma-butyrolactones with various substituents at the beta-position and the gamma-position. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：479 / 482
页数：4
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