An Implantable Peripheral Nerve Recording and Stimulation System for Experiments on Freely Moving Animal Subjects

被引：78
|
作者：
Lee, Byunghun [1 ,3 ]
Koripalli, Mukhesh K. [2 ]
Jia, Yaoyao [1 ]
Acosta, Joshua [2 ]
Sendi, M. S. E. [1 ]
Choi, Yoonsu [2 ]
Ghovanloo, Maysam [1 ]
机构：
[1] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30308 USA
[2] Univ Texas Rio Grande Valley, Dept Elect Engn, Edinburg, TX 78539 USA
[3] Incheon Natl Univ, Dept Elect Engn, Incheon 22012, South Korea
来源：
SCIENTIFIC REPORTS | 2018年 / 8卷
基金：
美国国家科学基金会;
关键词：
POWER TRANSMISSION; NEURAL INTERFACE; SPINAL-CORD; BRAIN;
D O I：
10.1038/s41598-018-24465-1
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A new study with rat sciatic nerve model for peripheral nerve interfacing is presented using a fully-implanted inductively-powered recording and stimulation system in a wirelessly-powered standard homecage that allows animal subjects move freely within the homecage. The Wireless Implantable Neural Recording and Stimulation (WINeRS) system offers 32-channel peripheral nerve recording and 4-channel current-controlled stimulation capabilities in a 3 x 1.5 x 0.5 cm(3) package. A bi-directional data link is established by on-off keying pulse-position modulation (OOK-PPM) in near field for narrow-band downlink and 433 MHz OOK for wideband uplink. An external wideband receiver is designed by adopting a commercial software defined radio (SDR) for a robust wideband data acquisition on a PC. The WINeRS-8 prototypes in two forms of battery-powered headstage and wirelessly-powered implant are validated in vivo, and compared with a commercial system. In the animal study, evoked compound action potentials were recorded to verify the stimulation and recording capabilities of the WINeRS-8 system with 32-ch penetrating and 4-ch cuff electrodes on the sciatic nerve of awake freely-behaving rats. Compared to the conventional battery-powered system, WINeRS can be used in closed-loop recording and stimulation experiments over extended periods without adding the burden of carrying batteries on the animal subject or interrupting the experiment.
引用
收藏
页数：12
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