Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units

被引：32

作者：

Poje, Julia E. ^{[1
]}

Kastratovic, Tamara ^{[1
]}

Macdonald, Andrew R. ^{[3
]}

Guillermo, Ana C. ^{[1
]}

Troetti, Steven E. ^{[1
]}

Jabado, Omar J. ^{[4
]}

Fanning, M. Leigh ^{[5
]}

Stefanovic, Darko ^{[5
,6
]}

Macdonald, Joanne ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Med, Div Expt Therapeut, New York, NY 10032 USA

[2] Univ Sunshine Coast, Genecol Res Ctr, Inflammat & Healing Res Cluster, Sch Sci & Engn, Sippy Downs, Qld, Australia

[3] Interfathom LLC, Chicago, IL 60680 USA

[4] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA

[5] Univ New Mexico, Dept Comp Sci, Albuquerque, NM 87131 USA

[6] Univ New Mexico, Ctr Biomed Engn, Albuquerque, NM 87131 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 35期

基金：

美国国家科学基金会;

关键词：

biosensors; DNA computing; molecular automata; molecular devices; nanotechnology; LOGIC GATES; COMPUTATION; DESIGN; INTEGRATION; NETWORK;

D O I：

10.1002/anie.201402698

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The monitoring of molecular systems usually requires sophisticated technologies to interpret nanoscale events into electronic-decipherable signals. We demonstrate a new method for obtaining read-outs of molecular states that uses graphics processing units made from molecular circuits. Because they are made from molecules, the units are able to directly interact with molecular systems. We developed deoxyribozyme-based graphics processing units able to monitor nucleic acids and output alphanumerical read-outs via a fluorescent display. Using this design we created a molecular 7-segment display, a molecular calculator able to add and multiply small numbers, and a molecular automaton able to diagnose Ebola and Marburg virus sequences. These molecular graphics processing units provide insight for the construction of autonomous biosensing devices, and are essential components for the development of molecular computing platforms devoid of electronics.

引用

页码：9222 / 9225

页数：4