DNA replication: damage tolerance at the assembly line

被引：0
|
作者：
Blastyak, Andras [1 ]
机构：
[1] Univ Szeged, Fac Sci & Informat, Dept Biochem & Mol Biol, H-6726 Szeged, Hungary
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2014年 / 39卷 / 07期
关键词：
damage tolerance; replication fork reversal; bidirectional replication; coupled replisomes; replication factory; ESCHERICHIA-COLI; LEADING-STRAND; IN-VIVO; REPLISOME; LESION; RECOMBINATION; POLYMERASE; HELICASE; REVEALS; MOTORS;
D O I：
10.1016/j.tibs.2014.05.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Damage tolerance mechanisms ensure resumption of DNA synthesis at damage replisome encounters. Replication fork reversal (RFR) is one such widely recognized mechanism that acts on replisomes where lagging strand synthesis continues upon leading strand synthesis block. The possibility to form such a structure is highly counter to our current understanding of the replisome dynamics of single replisomes. Here, I suggest a model that takes coupled bidirectional replisome organization into account to solve this apparent contradiction.
引用
收藏
页码：301 / 304
页数：4
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