The Beneficial Mechanical and Biological Outcomes of Thin Copper-Gallium Doped Silica-Rich Bio-Active Glass Implant-Type Coatings

被引：26

作者：

Stan, George E. ^{[1
]}

Tite, Teddy ^{[1
]}

Popa, Adrian-Claudiu ^{[1
]}

Chirica, Iuliana Maria ^{[1
]}

Negrila, Catalin C. ^{[1
]}

Besleaga, Cristina ^{[1
]}

Zgura, Irina ^{[1
]}

Sergentu, Any Cristina ^{[1
]}

Popescu-Pelin, Gianina ^{[2
]}

Cristea, Daniel ^{[3
]}

Ionescu, Lucia E. ^{[4
]}

Necsulescu, Marius ^{[4
]}

Fernandes, Hugo R. ^{[5
]}

Ferreira, Jose M. F. ^{[5
]}

机构：

[1] Natl Inst Mat Phys, RO-077125 Magurele, Romania

[2] Natl Inst Lasers Plasma & Radiat Phys, RO-077125 Magurele, Romania

[3] Transilvania Univ Brasov, Fac Mat Sci & Engn, Brasov 500068, Romania

[4] Army Ctr Med Res, RO-020012 Bucharest, Romania

[5] Univ Aveiro, Dept Mat & Ceram Engn, CICECO, P-3810193 Aveiro, Portugal

来源：

COATINGS | 2020年 / 10卷 / 11期

关键词：

implant coating; bioactive glass; copper doping; gallium doping; mechanical; cytocompatibility; antibacterial; SURFACE FREE-ENERGY; IN-VITRO; ANTIBACTERIAL; FILMS; ANGIOGENESIS; SCAFFOLDS; HYDROXYAPATITE; STRONTIUM; ADHESION; IONS;

D O I：

10.3390/coatings10111119

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Silica-based bioactive glasses (SBG) hold great promise as bio-functional coatings of metallic endo-osseous implants, due to their osteoproductive potential, and, in the case of designed formulations, suitable mechanical properties and antibacterial efficacy. In the framework of this study, the FastOs(R)BG alkali-free SBG system (mol%: SiO2-38.49, CaO-36.07, P2O5-5.61, MgO-19.24, CaF2-0.59), with CuO (2 mol%) and Ga2O3 (3 mol%) antimicrobial agents, partially substituting in the parent system CaO and MgO, respectively, was used as source material for the fabrication of intentionally silica-enriched implant-type thin coatings (similar to 600 nm) onto titanium (Ti) substrates by radio-frequency magnetron sputtering. The physico-chemical and mechanical characteristics, as well as the in vitro preliminary cytocompatibility and antibacterial performance of an alkali-free silica-rich bio-active glass coating designs was further explored. The films were smooth (R-RMS < 1 nm) and hydrophilic (water contact angle of similar to 65 degrees). The SBG coatings deposited from alkali-free copper-gallium co-doped FastOs(R)BG-derived exhibited improved wear performance, with the coatings eliciting a bonding strength value of similar to 53 MPa, Lc3 critical load value of similar to 4.9 N, hardness of similar to 6.1 GPa and an elastic modulus of similar to 127 GPa. The Cu and Ga co-doped SBG layers had excellent cytocompatibility, while reducing after 24 h the Staphylococcus aureus bacterial development with 4 orders of magnitude with respect to the control situations (i.e., nutritive broth and Ti substrate). Thereby, such SBG constructs could pave the road towards high-performance bio-functional coatings with excellent mechanical properties and enhanced biological features (e.g., by coupling cytocompatibility with antimicrobial properties), which are in great demand nowadays.

引用

页码：1 / 19

页数：19