We Are Ageing

被引：17
|
作者：
Kolovou, Genovefa D. [1 ]
Kolovou, Vana [1 ]
Mavrogeni, Sophie [1 ]
机构：
[1] Onassis Cardiac Surg Ctr, Dept Cardiol, Athens 17674, Greece
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
关键词：
GLUCAGON-LIKE PEPTIDE-1; ESTER TRANSFER PROTEIN; ANGIOTENSIN-CONVERTING ENZYME; DENSITY-LIPOPROTEIN CHOLESTEROL; GLYCOGEN-SYNTHASE KINASE-3; RABBIT SKELETAL-MUSCLE; AGE-RELATED DECLINE; E GENE POLYMORPHISM; LONG-LIFE FAMILY; HUMAN LONGEVITY;
D O I：
10.1155/2014/808307
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.
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页数：12
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