Genome Editing for Morbid Diseases: A Review

被引:0
|
作者
Samuel, Steffy R. [1 ]
Venugopal, Vidya [1 ]
Aswathy [1 ]
Babu, Bibil [1 ]
Sunil, Anuradha [1 ]
Pynadath, Meera K. [1 ]
机构
[1] Royal Dent Coll, Dept Oral Pathol & Microbiol, Palakkad, Kerala, India
关键词
Deoxyribonucleic acid; Ribonucleic acid; Nonhomologous end joining; Homology-directed repair; Zinc finger nuclease); Transcription activator-like effector nucleases; Clustered regularly interspaced short palindromic repeats; Cas9 (CRISPR associated gene); STRAND BREAK REPAIR; PROSPECTS; GENE;
D O I
10.5005/jp-journals-10037-1145
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Context: Gene editing is a technique involved in making specific changes in the genetic sequence of an organism. Specialized enzymes serve these purposes by cleaving at specific DNA sequences to edit the gene. Using this method an unwanted segment of DNA can be removed, or a desired segment of DNA can be inserted. Thus an organism's genetic constitution is changed or edited. Researchers claim gene editing has the potential to cure diseases and to produce genetically superior human offsprings the so-called designer babies. Despite numerous molecular applications, it is still at the controversial platform for clinical translation. Terror also lies in the creation of bioweapons if this highly sophisticated molecular technology is not wisely used. Objectives: Gene editing may offer a novel approach for the eradication of morbid diseases. Materials and methods: Data were obtained and analyzed from electronic database searches of relevant published literatures from Pubmed and Google Scholar. Conclusion: Utilising gene editing desired specific genetic changes can be made which in the future may help in the complete elimination of deadly diseases.
引用
收藏
页码:22 / 24
页数:3
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