Tocopherols enhance neurogenesis in dentate gyrus of adult rats

被引：19
|
作者：
Cuppini, R [1 ]
Ciaroni, S
Cecchini, T
Ambrogini, P
Ferri, P
Cuppini, C
Ninfali, P
Del Grande, P
机构：
[1] Univ Studi Urbino, Inst Sci Fisiol, I-61029 Urbino, Italy
[2] Univ Urbino, Ins Morphol Sci, I-61029 Urbino, Italy
[3] Univ Urbino, Inst Biol Chem Giorgio Fornaini, I-61029 Urbino, Italy
来源：
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH | 2002年 / 72卷 / 03期
关键词：
hippocampus; granule cells; vitamin E; neurogenesis; cell death;
D O I：
10.1024/0300-9831.72.3.170
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
In the dentate gyrus of the mammalian hippocampus, neurogenesis carries on throughout postnatal He. The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The effects of alpha- or beta- tocopherol supplementation on neurogenesis in the adult dentate gyrus were investigated by 5-bromo-2'-deoxyuridine labeling. Tocopherol was found to increase the survival of newborn cells and the total number of Granule cells in the adult rat dentate gyrus. Newborn cells were phenotypically characterized by expression of the immature neuron marker TOAD-64 (turned on after division-64). Therefore tocopherol in high doses possibly increases the number of granule cells in the dentate gyrus by saving newborn cells from death.
引用
收藏
页码：170 / 176
页数：7
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