Association of HLA-DR-DQ alleles, haplotypes, and diplotypes with type 1 diabetes in Saudis

被引：6

作者：

Eltayeb-Elsheikh, Nezar ^{[1
]}

Khalil, Eltahir ^{[2
]}

Mubasher, Mohamed ^{[3
]}

AlJurayyan, Abdullah ^{[1
]}

AlHarthi, Hanan ^{[1
]}

Omer, Waleed H. ^{[4
]}

Elghazali, Inas ^{[5
]}

Sherbeeni, Suphia M. ^{[6
]}

Alghofely, Mohammed A. ^{[6
]}

Ilonen, Jorma ^{[7
,8
]}

Elghazali, Gehad ^{[9
]}

机构：

[1] King Fahad Med City, Dept Pathol & Clin Lab Med, Riyadh 11525, Saudi Arabia

[2] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan

[3] Morehouse Sch Med, Biostat & Data Management Core, Atlanta, GA 30310 USA

[4] Natl Inst Genet, Div Human Genet, Mishima, Shizuoka, Japan

[5] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[6] King Fahad Med City, Endocrinol Dept, Riyadh, Saudi Arabia

[7] Univ Turku, Inst Biomed, Immunogenet Lab, Turku, Finland

[8] Turku Univ Hosp, Clin Microbiol Lab, Turku, Finland

[9] Sheikh Khalifa Med City, Dept Immunol, Abu Dhabi, U Arab Emirates

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2020年 / 36卷 / 08期

关键词：

haplotypes; HLA alleles; Saudis; type; 1; diabetes; CLASS-II ALLELES; GENETIC SUSCEPTIBILITY; MELLITUS; RISK; CHILDREN; POPULATION; RESISTANCE; CHILDHOOD; PREVALENCE; ANTIGENS;

D O I：

10.1002/dmrr.3345

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Type 1 diabetes (T1D) is an autoimmune disease that affects many children worldwide. Genetic factors and environmental triggers play crucial interacting roles in the aetiology. This study aimed to assess the contribution of HLA-DRB1-DQA1-DQB1 alleles, haplotypes, and genotypes to the risk of T1D among Saudis. Methods A total of 222 children with T1D and 342 controls were genotyped for HLA-DRB1, -DQA1, and -DQB1 using reverse sequence-specific oligonucleotide (rSSO) Lab Type high definition (HD) kits. Alleles, haplotypes, and diplotypes were compared between cases and controls using the SAS statistical package. Results DRB1*03:01-DQA1*05:01-DQB1*02:01 (32.4%; OR = 3.68; P-c < .0001), DRB1*04:05-DQA1*03:02-DQB1*03:02 (6.6%; OR = 6.76; P-c < .0001), DRB1*04:02-DQA1*03:01-DQB1*03:02 (6.0%; OR = 3.10; P-c = .0194), DRB1*04:01-DQA1*03:01-DQB1*03:02 (3.7%; OR = 4.22; P-c = .0335), and DRB1*04:05-DQA1*03:02-DQB1*02:02 (2.7%; OR = 6.31; P-c = .0326) haplotypes were significantly increased in cases compared to controls, whereas DRB1*07:01-DQA1*02:01-DQB1*02:02 (OR = 0.41; P-c = .0001), DRB1*13:01-DQA1*01:03-DQB1*06:03 (OR = 0.05; P-c < .0001), DRB1*15:01-DQA1*01:02-DQB1*06:02 (OR = 0.03; P-c < .0001), and DRB1*11:01-DQA1*05:05-DQB1*03:01 (OR = 0.07; P-c = .0291) were significantly decreased. Homozygous DRB1*03:01-DQA1*05:01-DQB1*02:01 genotypes and combinations of DRB1*03:01-DQA1*05:01-DQB1*02:01 with DRB1*04:05-DQA1*03:02-DQB1*03:02, DRB1*04:02-DQA1*03:01-DQB1*03:02, and DRB1*04:01-DQA1*03:01-DQB1*03:02 were significantly increased in cases than controls. Combinations of DRB1*03:01-DQA1*05:01-DQB1*02:01 with DRB1*07:01-DQA1*02:01-DQB1*02:02 and DRB1*13:02-DQA1*01:02-DQB1*06:04 showed low OR values but did not remain significantly decreased after Bonferroni correction. Conclusions HLA-DRB1-DQA1-DQB1 alleles, haplotypes, and diplotypes in Saudis with T1D are not markedly different from those observed in Western and Middle-Eastern populations but are quite different than those of East Asians.

引用

页数：10

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