Immune modulation by mesenchymal stem cells

被引：287
|
作者：
Rasmusson, Ida [1 ]
机构：
[1] Huddinge Univ Hosp, Div Clin Immunol F79, SE-14186 Stockholm, Sweden
来源：
EXPERIMENTAL CELL RESEARCH | 2006年 / 312卷 / 12期
关键词：
multipotent stem cells; immune system; prostaglandin; T cells; graft versus host disease; cytotoxicity; proliferation;
D O I：
10.1016/j.yexcr.2006.03.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mesenchymal stem cells (MSCs) have been shown to suppress activation of T cells both in vivo and in vitro. In vivo, this may be a way for the body to maintain homeostasis and inhibit immune activation in distinct compartments, such as the bone marrow and the interface between mother and fetus. MSCs modulate the immune function of the major cell populations involved in alloantigen recognition and elimination, including antigen presenting cells, T cells, and natural killer cells. The molecular mechanism that mediates the immunosuppressive effect of MSCs is not completely understood. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：2169 / 2179
页数：11
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