Cytotoxic Terpenoids from the Fruits of Vitex trifolia L.

被引：34

作者：

Wu, Jun ^{[1
]}

Zhou, Tong ^{[1
]}

Zhang, Shu-wei ^{[1
]}

Zhang, Xiao-hui ^{[1
]}

Xuan, Li-jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 04期

关键词：

Vitex trifolia; Verbenaceae; fruits; diterpenoids; antiproliferation; cell cycle; DITERPENES; APOPTOSIS;

D O I：

10.1055/s-0028-1112211

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new labdane-type diterpenoids vitetrifolin H (1) and vitetrifolin 1 (2), and one new monoterpenoid vitexoid (3), were isolated from the fruits of Vitex trifolia L., together with seven known diterpenoids. Structures of all compounds were elucidated by extensive spectroscopic methods. All these compounds exhibited inhibition of Hela cell proliferation, with IC50 values in the range of 4-28 mu M. In addition, vitetrifolin 1 (2) induced cell cycle G(0)/G(1) phase arrest and apoptosis of Hela cells.

引用

页码：367 / 370

页数：4

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