Pulmonary drug delivery by powder aerosols

被引：142
|
作者：
Yang, Michael Yifei [1 ]
Chan, John Gar Yan [1 ]
Chan, Hak-Kim [1 ]
机构：
[1] Univ Sydney, Fac Pharm A15, Adv Drug Delivery Grp, Sydney, NSW 2006, Australia
来源：
JOURNAL OF CONTROLLED RELEASE | 2014年 / 193卷
基金：
澳大利亚研究理事会;
关键词：
Dry powder inhaler; Pharmaceutical aerosol; Lung deposition; SPECT imaging; Pulmonary drug delivery; Dry powder formulation; COMPUTATIONAL FLUID-DYNAMICS; CYSTIC-FIBROSIS PATIENTS; PEAK INSPIRATORY FLOW; REGIONAL LUNG DEPOSITION; METERED-DOSE INHALER; DRY-POWDER; IN-VITRO; PARTICLE-SIZE; TERBUTALINE SULFATE; GAMMA-SCINTIGRAPHY;
D O I：
10.1016/j.jconrel.2014.04.055
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The efficacy of pharmaceutical aerosols relates to its deposition in the clinically relevant regions of the lungs, which can be assessed by in vivo lung deposition studies. Dry powder formulations are popular as devices are portable and aerosolisation does not require a propellant. Over the years, key advancements in dry powder formulation, device design and our understanding on the mechanics of inhaled pharmaceutical aerosol have opened up new opportunities in treatment of diseases through pulmonary drug delivery. This review covers these advancements and future directions for inhaled dry powder aerosols. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：228 / 240
页数：13
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