Human interferon-λ3 is a potent member of the type III interferon family

被引：136

作者：

Dellgren, C. ^{[1
]}

Gad, H. H. ^{[1
]}

Hamming, O. J. ^{[1
]}

Melchjorsen, J. ^{[1
]}

Hartmann, R. ^{[1
]}

机构：

[1] Univ Aarhus, Struct Biol Ctr, Dept Mol Biol, DK-8000 Aarhus C, Denmark

来源：

GENES AND IMMUNITY | 2009年 / 10卷 / 02期

基金：

英国医学研究理事会;

关键词：

interferon; antiviral; cytokines; protein refolding; IFN-LAMBDA; EXPRESSION; CELLS;

D O I：

10.1038/gene.2008.87

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but use a separate receptor complex composed of the IL-10R2 and the unique IFN-lambda R1 receptor chains. We have established a simple and efficient expression system to produce highly pure and active IFN-lambda of the three human IFN-lambda isoforms (IFN-lambda 1, -lambda 2 and -lambda 3) and used this to compare the biological activity of the different IFN-lambda subtypes. Surprisingly, we found IFN-lambda 3 to possess the highest specific activity of the human IFN-lambda subtypes, exhibiting a twofold higher activity than IFN-lambda 1 and a 16-fold higher activity than IFN-lambda 2. Furthermore, in comparison with the commercially available preparations of IFN-lambda 1 and -lambda 2, we found our IFN-lambda preparation to be superior in activity.

引用

页码：125 / 131

页数：7

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