Multivalent dendrons for high-affinity adhesion of proteins to DNA

被引：62
|
作者：
Kostiainen, Mauri A.
Szilvay, Geza R.
Smith, David K.
Linder, Markus B.
Ikkala, Olli
机构：
[1] Aalto Univ, Dept Engn Phys & Math, Espoo 02015, Finland
[2] Aalto Univ, Ctr New Mat, Espoo 02015, Finland
[3] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England
[4] Univ Helsinki, Inst Biotechnol, Res Program Struct Biol & Biophys, FIN-00014 Helsinki, Finland
[5] VTT Biotechnol, FIN-02044 Helsinki, Finland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期
关键词：
dendrimers; DNA; multivalency; protein modifications; self-assembly;
D O I：
10.1002/anie.200504540
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Strength in numbers: Multivalent dendrons that have an N-maleimido group at the focal point can be used to construct monodisperse one-to-one protein-dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high-affinity DNA binding to a protein of choice. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3538 / 3542
页数：5
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