Fibrous dysplasia. Clinical review and therapeutic management

被引:15
|
作者
Florez, Helena [1 ]
Peris, Pilar [1 ]
Guanabens, Nuria [1 ]
机构
[1] Univ Barcelona, Hosp Clin, Serv Reumatol, Barcelona, Spain
来源
MEDICINA CLINICA | 2016年 / 147卷 / 12期
关键词
Fibrous dysplasia; McCune-Albright syndrome; Bisphosphonates; Denosumab; FGF-23; INTRAVENOUS PAMIDRONATE; BONE; MUTATIONS; DENOSUMAB;
D O I
10.1016/j.medcli.2016.07.030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fibrous dysplasia is a skeletal disorder that is associated with a wide spectrum of clinical manifestations, including localized asymptomatic forms and extensive severe forms with severe bone deformities and endocrinological alterations, depending on age, location, extent and associated processes. Although the treatment of choice is based on bisphosphonates, the therapeutic efficacy of these agents in the control of disease activity remains uncertain. This article reviews the current data available on the treatment of this disease as well as the preliminary data on new therapeutic approaches. (C) 2016 Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码:547 / 553
页数:7
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