IQGAP1 regulation and roles in cancer

被引：160
|
作者：
Johnson, Michael [1 ]
Sharma, Manisha [1 ]
Henderson, Beric R. [1 ]
机构：
[1] Univ Sydney, Westmead Hosp, Westmead Millennium Inst, Westmead Inst Canc Res, Westmead, NSW 2145, Australia
来源：
CELLULAR SIGNALLING | 2009年 / 21卷 / 10期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
IQGAP1; Beta-catenin; Cancer; Cell adhesion; Cell migration; EPITHELIAL-MESENCHYMAL TRANSITION; ADENOMATOUS POLYPOSIS-COLI; RASGAP-RELATED PROTEIN; BETA-CATENIN; E-CADHERIN; CELL-PROLIFERATION; BINDING PROTEIN; ACTIN-BINDING; N-CADHERIN; CDC42;
D O I：
10.1016/j.cellsig.2009.02.023
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
IQGAP1 is a key mediator of several distinct cellular processes, in particular cytoskeletal rearrangements. Recent studies have implicated a potential role for IQGAP1 in cancer, supported by the over-expression and distinct membrane localisation of IQGAP1 observed in a range of tumours. IQGAP1 is thought to contribute to the transformed cancer cell phenotype by regulating signalling pathways involved in cell proliferation and transformation, weakening of cell:cell adhesion contacts and stimulation of cell motility and invasion. In this review we discuss these different functional and regulatory roles of IQGAP1 and its homologues in relation to their potential impact on tumourigenesis. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：1471 / 1478
页数：8
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