Aberrant Wnt Signaling in Leukemia

被引：66
|
作者：
Staal, Frank J. T. [1 ]
Famili, Farbod [1 ]
Perez, Laura Garcia [1 ]
Pike-Overzet, Karin [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
来源：
CANCERS | 2016年 / 8卷 / 09期
关键词：
Wnt signaling; leukemic stem cell; leukemia; AML; CML; CLL; ALL; pathogenesis; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; SMALL-MOLECULE INHIBITORS; WNT/BETA-CATENIN PATHWAY; TYROSINE KINASE-ACTIVITY; BETA-CATENIN; TUMOR-SUPPRESSOR; BCR-ABL;
D O I：
10.3390/cancers8090078
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment.
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页数：15
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