ENFORCED TUMOR SPECIFIC MHC-I HETEROGENEITY IN TRIPLE NEGATIVE BREAST CANCER DRIVES IMMUNOTHERAPY RESISTANCE

被引：2
|
作者：
Taylor, Brandie [1 ]
Balko, Justin [2 ]
Sanders, Melinda [2 ]
Gonzalez-Ericsson, Paula [2 ]
Sanchez, Violeta [2 ]
机构：
[1] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Med Ctr, Nashville, TN USA
来源：
JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2021年 / 9卷
关键词：
D O I：
10.1136/jitc-2021-SITC2021.318
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
318
引用
收藏
页码：A342 / A342
页数：1
相关论文
共 50 条
  • [1] Implications of Heterogeneity in Breast Tumor Cell MHC-I Expression on Immunity and Therapeutic Resistance
    Taylor, Brandie C.
    Sun, Xiaopeng
    Balko, Justin
    Gonzalez-Ericsson, Paula
    Sanders, Melinda
    CANCER RESEARCH, 2023, 83 (05)
  • [2] NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer
    Taylor, Brandie C.
    Sun, Xiaopeng
    Gonzalez-Ericsson, Paula I.
    Sanchez, Violeta
    Sanders, Melinda E.
    Wescott, Elizabeth C.
    Opalenik, Susan R.
    Hanna, Ann
    Chou, Shu-Ting
    Van Kaer, Luc
    Gomez, Henry
    Isaacs, Claudine
    Ballinger, Tarah J.
    Santa-Maria, Cesar A.
    Shah, Payal D.
    Dees, Elizabeth C.
    Lehmann, Brian D.
    Abramson, Vandana G.
    Pietenpol, Jennifer A.
    Balko, Justin M.
    CANCER DISCOVERY, 2024, 14 (02) : 290 - 307
  • [3] Genetic Heterogeneity, Tumor Microenvironment and Immunotherapy in Triple-Negative Breast Cancer
    Kudelova, Eva
    Smolar, Marek
    Holubekova, Veronika
    Hornakova, Andrea
    Dvorska, Dana
    Lucansky, Vincent
    Koklesova, Lenka
    Kudela, Erik
    Kubatka, Peter
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [4] TUMOR SPECIFIC MHC-I EXPRESSION DETERMINES THE LOCAL IMMUNE MICROENVIRONMENT IN BREAST CANCER
    Sun, Xiaopeng
    Taylor, Brandie
    Ericsson, Paula Gonzalez
    Sanchez, Violeta
    Balko, Justin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A117 - A117
  • [5] Targeting MHC-I inhibitory pathways for cancer immunotherapy
    Wang, Jun
    Lu, Qiao
    Chen, Xufeng
    Aifantis, Iannis
    TRENDS IN IMMUNOLOGY, 2024, 45 (03) : 177 - 187
  • [6] Recent progress on MHC-I epitope prediction in tumor immunotherapy
    Wang, Xiangyi
    Yu, Zhaojin
    Liu, Wensi
    Tang, Haichao
    Yi, Dongxu
    Wei, Minjie
    AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (06): : 2401 - 2416
  • [7] Tumor microenvironment and immunotherapy for triple-negative breast cancer
    Guo, Zijie
    Zhu, Ziyu
    Lin, Xixi
    Wang, Shenkangle
    Wen, Yihong
    Wang, Linbo
    Zhi, Lili
    Zhou, Jichun
    BIOMARKER RESEARCH, 2024, 12 (01)
  • [8] Triple negative breast cancer: Immunogenicity, tumor microenvironment, and immunotherapy
    Loizides, Sotiris
    Constantinidou, Anastasia
    FRONTIERS IN GENETICS, 2023, 13
  • [9] Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation
    Zhang, Biying
    Li, Jiao
    Hua, Qingling
    Wang, Haihong
    Xu, Guojie
    Chen, Jiayuan
    Zhu, Ying
    Li, Ruiqi
    Liang, Qing
    Wang, Lanqing
    Jin, Min
    Tang, Jing
    Lin, Zhenyu
    Zhao, Lei
    Zhang, Dejun
    Yu, Dandan
    Ren, Jinghua
    Zhang, Tao
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2023, 11 (01)
  • [10] MHC-I genotype and tumor mutational burden predict response to immunotherapy
    Goodman, Aaron M.
    Castro, Andrea
    Pyke, Rachel Marty
    Okamura, Ryosuke
    Kato, Shumei
    Riviere, Paul
    Frampton, Garrett
    Sokol, Ethan
    Zhang, Xinlian
    Ball, Edward D.
    Carter, Hannah
    Kurzrock, Razelle
    GENOME MEDICINE, 2020, 12 (01)
12345