Short-term culture of organotypic tumor spheroids derived from patient xenografts in a novel 3D microfluidic chip predicts in vivo response of targeted therapies

被引：0
|
作者：
Aref, Amir [1 ]
Ivanova, Elena [1 ]
Chambers, Emily [1 ]
Portell, Andrew [1 ]
Jenkins, Russell [1 ]
Lin, Mika [1 ]
Xu, Man [1 ]
Haworth, Jacob [1 ]
Bahcall, Magda [1 ]
Paweletz, Cloud [1 ]
Janne, Pasi [1 ]
机构：
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
CANCER RESEARCH | 2018年 / 78卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2018-988
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
988
引用
收藏
页数：2
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    Larios, Dalia
    Piel, Brandon P.
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    Coakley, Raven Vlahos
    Bartels, Alan
    Bowden, Michaela
    Herbert, Zach
    Hill, Sarah
    Gilhooley, Sean
    Carter, Jacob
    Canadas, Israel
    Thai, Tran C.
    Kitajima, Shunsuke
    Chiono, Valeria
    Paweletz, Cloud P.
    Barbie, David A.
    Kamm, Roger D.
    Jenkins, Russell W.
    [J]. LAB ON A CHIP, 2018, 18 (20) : 3129 - 3143
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    Gage, Jacob A.
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    Skinner, Sheri
    Dehghani, Mehdi
    Rosenblatt, Kevin P.
    Li, Wenliang
    Amato, Robert J.
    Souza, Glauco R.
    [J]. CANCER RESEARCH, 2016, 76
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    Aref, Amir
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    Lizotte, Patrick
    Huang, Wei
    Palakurthi, Sangeetha
    Kirschmeier, Paul
    Barbie, David
    Paweletz, Cloud
    Janne, Pasi
    Wong, Kwok-Kin
    [J]. CANCER RESEARCH, 2017, 77
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    Bircsak, Kristin M.
    Shepherd, Peter
    Queiroz, Karla
    Farach-Carson, Mary C.
    Constantinou, Pamela E.
    Saleh, Anthony
    Navone, Nora
    Harrington, Daniel A.
    [J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2020, (166): : 1 - 17
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    Hodge, Philip
    Lynn, Michael
    Edenfield, Jeff
    Lewis, Michael T.
    Crosswell, Howland E.
    DesRochers, Teresa M.
    [J]. CANCER RESEARCH, 2019, 79 (13)
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    Price, Leo
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    Anderle, N.
    Hennenlotter, J.
    Stenzl, A.
    Schmees, C.
    [J]. EUROPEAN JOURNAL OF CANCER, 2016, 69 : S55 - S56
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    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018, 37
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