The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

被引：263
|
作者：
Lankat-Buttgereit, Brigitte [1 ]
Goeke, Ruediger [1 ]
机构：
[1] Univ Marburg, Fac Med, Dept Gastroenterol Endocrinol & Metab, D-35033 Marburg, Germany
来源：
BIOLOGY OF THE CELL | 2009年 / 101卷 / 06期
关键词：
cancer; cell cycle; programmed cell death 4 (Pdcd4); signal transduction; tumour suppressor; TRANSFORMATION SUPPRESSOR; PROTEIN PDCD4; UP-REGULATION; EUKARYOTIC TRANSLATION; GENE-EXPRESSION; CELL-CYCLE; KAPPA-B; CARCINOMA; APOPTOSIS; INVASION;
D O I：
10.1042/BC20080191
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pdcd4 (programmed cell death 4) has been known as a tumour suppressor gene and potential target for anticancer therapies for several years. Initially, Pdcd4 was identified as a gene that is up-regulated during apoptosis, but its precise role still remains to be defined. However, there is increasing evidence that Pdcd4 levels influence transcription, as well as translation, modulate different signal transduction pathways and might act as a tumour suppressor. Interestingly, recent data suggest that Pdcd4 function may depend on cell type and/or genetic background. This review summarizes the current knowledge regarding the function and regulation of Pdcd4.
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收藏
页码：309 / 317
页数：9
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