Pancreatic lipase inhibitory stilbenoids from the roots of Vitis vinifera

被引：18
|
作者：
Kim, Young-Mog [1 ]
Lee, Eun-Woo [2 ]
Eom, Sung-Hwan [1 ]
Kim, Tae Hoon [3 ]
机构：
[1] Pukyong Natl Univ, Dept Food Sci & Technol, Pusan, South Korea
[2] Dong Eui Univ, Dept Life Sci & Biotechnol, Pusan, South Korea
[3] Daegu Haany Univ, Dept Herbal Med Pharmacol, Gyongsan, South Korea
来源：
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2014年 / 65卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Obesity; pancreatic lipase; stilbenenoids; Vitis vinifera; wilsonol C; RESVERATROL; OLIGOSTILBENES;
D O I：
10.3109/09637486.2013.832172
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Bioassay-guided isolation of an aqueous methanolic extract of Vitis vinifera using pancreatic lipase inhibitory activity led to isolation of seven stilbenoids, wilsonol C (1), heyneanol A (2), ampelopsin A (3), pallidol A (4), cis-piceid (5), trans-piceid (6) and trans-resveratrol (7). The structures were established on the basis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhibitory effects on pancreatic lipase, and stilbenoid 1 exhibited potent inhibitory effect on pancreatic lipase with IC50 values of 6.7 +/- 0.7 mu M.
引用
收藏
页码：97 / 100
页数：4
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