Psychiatric genetics in China: achievements and challenges

被引:13
|
作者
Liu, C. [1 ,2 ]
Saffen, D. [3 ]
Schulze, T. G. [4 ,5 ,6 ,7 ]
Burmeister, M. [8 ,9 ,10 ,11 ]
Sham, P. C. [12 ]
Yao, Y-g [13 ]
Kuo, P-H [14 ,15 ,17 ]
Chen, C. [1 ]
An, Y. [16 ,17 ]
Dai, J. [18 ]
Yue, W. [19 ]
Li, M. X. [12 ]
Xue, H. [20 ,21 ]
Su, B. [22 ,23 ]
Chen, L. [3 ]
Shi, Y. [11 ]
Qiao, M. [24 ]
Liu, T. [25 ]
Xia, K. [1 ,26 ]
Chan, R. C. K. [27 ]
机构
[1] Cent South Univ, State Key Lab Med Genet China, Changsha 410078, Hunan, Peoples R China
[2] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA
[3] Fudan Univ, Dept Cellular & Genet Med, Shanghai 200433, Peoples R China
[4] Univ Gottingen, Univ Med Ctr, Dept Psychiat & Psychotherapy, D-37073 Gottingen, Germany
[5] Univ Munich, Inst Psychiat Phen & Genom, Munich, Germany
[6] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
[7] Heidelberg Univ, Univ Med Ctr Mannheim, Cent Inst Mental Hlth Mannheim, Dept Genet Epidemiol Psychiat, Mannheim, Germany
[8] Univ Michigan, Mol & Behav Neurosci Inst, Dept Psychiat, Ann Arbor, MI 48109 USA
[9] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
[10] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA
[11] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China
[12] Univ Hong Kong, Dept Psychiat, Pokfulam, Hong Kong, Peoples R China
[13] Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Peoples R China
[14] Natl Taiwan Univ, Coll Publ Hlth, Dept Publ Hlth, Taipei 10764, Taiwan
[15] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan
[16] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China
[17] Fudan Univ, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China
[18] South Cent Univ Nationalities, Wuhan Inst Neurosci & Neuroengn, Wuhan, Peoples R China
[19] Peking Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100871, Peoples R China
[20] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China
[21] Hong Kong Univ Sci & Technol, Appl Genom Ctr, Hong Kong, Peoples R China
[22] Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Kunming Inst Zool, Kunming, Yunnan, Peoples R China
[23] Chinese Acad Sci, Kunming Primate Res Ctr, Kunming, Yunnan, Peoples R China
[24] Shandong Univ Tradit Chinese Med, Sch Basic Med, Inst Tradit Chinese Med Theory, Jinan, Peoples R China
[25] Shenzhen Kangning Hosp, Shenzhen Inst Mental Hlth, Shenzhen Key Lab Psychol Healthcare, Shenzhen, Peoples R China
[26] Cent South Univ, Sch Life Sci, Changsha, Hunan, Peoples R China
[27] Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing, Peoples R China
关键词
GENOME-WIDE ASSOCIATION; MAJOR DEPRESSIVE DISORDER; HAN CHINESE; COMMON VARIANTS; BIPOLAR DISORDER; SCHIZOPHRENIA; RISK; SUSCEPTIBILITY; LOCI; GWAS;
D O I
10.1038/mp.2015.95
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Psychiatric genetics is still in its early stages in China, but has great potential and a promising future. Many of the elements and resources required for the dynamic growth of this field are already in place. At the same time, there are many hurdles to overcome. Enhanced education to promote public awareness of the importance of genetic research, increased funding for individual labs and collaborative research, increased participation of clinicians in patient ascertainment and testing, and improved academic evaluation policies are all vital to fostering collaborative research and the formation of large consortia needed to create a science of genetics tailored to the needs of the Chinese population. We hope that collaborative efforts of the entire psychiatric genetics community, with active input from the researchers who are working on neuroscience biology, will lead to better ways of diagnosing, treating and preventing psychiatric diseases in China, thereby easing the burdens of individual sufferers and their families and the social and economic burdens of country as a whole. The ideas discussed at the First Summit on Chinese Psychiatric enetics in 2004 were further developed at the Second Summit n Chinese Psychiatric Genetics in Kunming, Yunnan (12-13 April) and presentations and discussions from both Summits contributed to the content of the present paper. The Third Summit on Chinese Psychiatric Genetics will be held in Wuxi, Jiangsu in 2016. We strongly believe that these Summits will become an important orum for psychiatric genetics research in China and will serve as a seed from which a new research society will grow. We welcome all interested researchers, both international and from China, to join us at our next meeting in Wuxi.
引用
收藏
页码:4 / 9
页数:6
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