Synthesis of triazoles, oxadiazoles and condensed Heterocyclic compounds containing cinchopheny and studies on biological activity of representative compounds

Compounds 2-arylamino-5-cinchophenyl-1,3,4-oxadiazoline (7) and 3-thio-4-amino-5-cinchophenyl-1,2,4-triazole (3) have been synthesized utilizing cinchophen as the starting material. The compound 3-cinchopheny-s-triazolo[3,4-b]-1,2,3,4-thiatriazole (4) was prepared from compound 3. Condensation of 3 with aromatic acid in the presence of POCl3 gave 10 new 6-aryi-3-cinchopheny-1,2,4-triazolo[3,4-b]- 1,3,4-thiadiazoles (5). Some of the representative compounds were screened for antibacterial activity. The structures of these new compounds have been confirmed by means of elemental analysis, IR, H-1 NMR and MS.