Comparing the growth kinetics of cell populations in two and three dimensions

被引：50

作者：

Radszuweit, M. ^{[1
]}

Block, M. ^{[1
]}

Hengstler, J. G. ^{[2
]}

Schoell, E. ^{[1
]}

Drasdo, D. ^{[3
,4
]}

机构：

[1] Tech Univ Berlin, Inst Theoret Phys, D-10623 Berlin, Germany

[2] Univ Dortmund, Inst Arbeitsphysiol, D-44139 Dortmund, Germany

[3] French Natl Inst Comp Sci & Control, F-8153 Le Chesnay, France

[4] Univ Leipzig, Interdisciplinary Ctr Bioinformat, D-04107 Leipzig, Germany

来源：

PHYSICAL REVIEW E | 2009年 / 79卷 / 05期

关键词：

cellular biophysics; monolayers; Monte Carlo methods; tumours; TUMOR-GROWTH; CYCLE SYNCHRONIZATION; PROLIFERATION; PROGRESSION; APOPTOSIS; DYNAMICS; MODEL; SIMULATION; SPHEROIDS; MIGRATION;

D O I：

10.1103/PhysRevE.79.051907

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We study the kinetics of growing cell populations by means of a kinetic Monte Carlo method. By applying the same growth mechanism to a two-dimensional (2D) and a three-dimensional (3D) model, and making direct comparison with experimental studies, we show that both models exhibit similar behavior. Based on this we propose a method for establishment of a mapping between the 2D and 3D results. Additionally, we present an analytic approach to obtain the time evolution, and show in case of the 3D model how synchronization effects can influence the growth kinetics. Finally, we compare the results of our models to experimental data of the growth kinetics of 2D monolayers and 3D NIH3T3 xenografts in mice.

引用

页数：12

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