Confirmation of a gene for multiple sclerosis (MS) to chromosome region 19q13.3

被引：0
|
作者：
Lucotte, G [1 ]
机构：
[1] Mol Neurogenet Lab, Paris, France
来源：
GENETIC COUNSELING | 2002年 / 13卷 / 02期
关键词：
multiple sclerosis (MS); genowide linkage analysis; localization in 19q13.3; severity gene; apolipoprotein E (ApoE) epsilon A allele;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
To identify the chromosomal localizations of the multiple sclerosis (MS) genes, we conducted a genomewide linkage analysis using eighteen affected families. A MS gene is linked to markers located in the 19q13.3 region (multipoint lod-score = 2.1). Apolipoprotein E (ApoE) gene, located in this region, is an excellent candidate gene for MS because the ApoEe4 allele is acting as a severity allele in the disease.
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页码：133 / 138
页数：6
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