Synthesis of Polychloromethyl-Containing Indolines via Metal-Free Radical Arylpolychloromethylation of Unactivated Alkenes

被引：7
|
作者：
Li, Wenlan [1 ]
Sun, Yitong [2 ]
Yao, Yongchao [2 ]
Xu, Ying [1 ]
Li, Peng [3 ]
Liu, Yingjie [1 ]
Liang, Deqiang [2 ]
机构：
[1] Harbin Univ Commerce, Res Ctr Life Sci & Environm Sci, Harbin 150076, Heilongjiang, Peoples R China
[2] Kunming Univ, Dept Chem, Kunming 650214, Yunnan, Peoples R China
[3] Heilongjiang Nursing Coll, Harbin 150000, Heilongjiang, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 39卷 / 06期
基金：
中国国家自然科学基金;
关键词：
unactivated alkenes; polychloromethylation; indolines; radical reaction; ACTIVATED ALKENES; BARBAMIDE; DEAROMATIZATION; HALOALKYLATION; BIOSYNTHESIS; SINTOKAMIDES; HALOGENATION; METABOLITE; CATALYSIS; ORIGIN;
D O I：
10.6023/cjoc201901047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free polychloromethylation/cyclization cascade of anlines is presented, which provides an access to polychloromethyl-substituted indolines with unactivated alkenes as radical acceptors and dicumyl peroxide (DCP) as the initiator. The inexpensive solvents of polychoromethanes (i.e., CH2Cl2, CHCl3 and CCl4) were used in the reaction as di- or tri-chloromethylating agents. This work has advantages of easy operation, mild conditions, low cost, and broad substrate scope.
引用
收藏
页码：1727 / 1734
页数：8
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