Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein

被引：27
|
作者：
Gomez, Alvin [1 ]
Ingelman-Sundberg, Magnus [1 ]
机构：
[1] Karolinska Inst, Pharmacogenet Sect, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden
来源：
PHARMACOGENOMICS | 2009年 / 10卷 / 07期
关键词：
cytochrome P450; DNA methylation; epigenetics histone modifications; miRNA; ISLAND METHYLATOR PHENOTYPE; TUMOR-SPECIFIC EXPRESSION; INDUCED GENE-EXPRESSION; PREGNANE X RECEPTOR; CPG-ISLANDS; MICROSATELLITE INSTABILITY; CHROMATIN MODIFICATIONS; HISTONE DEACETYLASE; COLORECTAL-CANCER; NONCODING RNAS;
D O I：
10.2217/PGS.09.56
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Although pharmacogenetics has been instrumental in describing interindividual variations in drug metabolism, epigenetic factors offer another blanket of information that could give a more vivid picture and help in developing a more personalized therapy. The dynamic aspect of epigenetics could likewise provide more definite answers to the role of changing environmental factors in drug response: the bridge that connects the environment to the genome. In this review we discuss known epigenetic and microRNA-dependent regulation of the human drug-metabolizing cytochromes P450 to help explain the unknown factors of variable drug response.
引用
收藏
页码：1067 / 1076
页数：10
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